EMBRACE NTM ASIA
Asian Bronchiectasis Registry

When the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC) was initiated in 2012, bronchiectasis was largely understudied in Asia, with limited evidence-based treatments and sparse data on its epidemiology, co-morbidities, pathophysiology, severity, and prognosis. Few longitudinal or cross-sectional studies existed to guide clinical practice in the region.

To address this gap and provide meaningful, regionally relevant insights, a large-scale, longitudinal observational study of bronchiectasis is essential, requiring the enrollment of thousands of patientsโ€”far beyond the capacity of any single center in Asia.

To meet this need, EMBRACE ASIA is expanding its efforts to establish a comprehensive, pan-Asian registry of bronchiectasis patients. This initiative aims to become the largest and most impactful bronchiectasis patient data registry in Asia, fostering collaboration across the region.

Overview

Understanding Bronchiectasis

Understanding Bronchiectasis: A Comprehensive Guide

Welcome to your central resource for understanding bronchiectasis. This page provides a complete overview of the condition, from symptoms and causes to diagnosis, treatment, and effective self-management strategies.

What is Bronchiectasis?

Bronchiectasis is a chronic and progressive lung condition characterized by the abnormal and permanent widening (dilatation) of the bronchi, which are the large- and medium-sized airways in the lungs. This structural change prevents the airways from clearing mucus effectively.

This leads to a build-up of thick, sticky mucus, creating an environment where bacteria can thrive. The condition is often described as a “vicious vortex” or cycle: the excess mucus leads to recurrent and severe chest infections, which in turn cause inflammation and further damage to the airway walls, worsening the widening and mucus build-up.

The “Vicious Vortex” Cycle

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1. Airway Damage

Bronchi are widened and damaged.

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2. Mucus Buildup

Mucus cannot be cleared effectively.

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3. Infection

Bacteria thrive in the mucus, causing infections.

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4. Inflammation

Infections cause inflammation, leading to more damage.

Key Symptoms

While symptoms and their severity can vary significantly from person to person (a state known as being highly heterogeneous), some are very common. Periodic flare-ups, known as exacerbations, are a key feature and a primary driver of disease progression.

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Chronic Cough

A persistent, daily cough that is often productive, meaning it brings up mucus (sputum).

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Sputum Production

Producing large volumes of mucus on a regular basis.

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Breathlessness

Feeling short of breath (dyspnea), especially with exertion.

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Recurrent Chest Infections

An increased susceptibility to infections that may require antibiotics.

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Fatigue

Persistent tiredness and lack of energy.

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Other Symptoms

Some may also experience wheezing, chest pain, or coughing up blood (hemoptysis).

Causes and Risk Factors

In many cases, bronchiectasis arises as a consequence of another condition or event. However, for a significant number of individuals, the specific cause remains unknown; this is termed ‘idiopathic bronchiectasis’.

Particularly infections like pneumonia, measles, or whooping cough that occurred during childhood.

Such as Primary Ciliary Dyskinesia (PCD), where the tiny hair-like structures (cilia) that clear mucus are dysfunctional, or Alpha-1 Antitrypsin Deficiency.

Inherited or acquired conditions that weaken the immune system, making infections more common.

Including severe, poorly controlled asthma or Chronic Obstructive Pulmonary Disease (COPD).

Such as rheumatoid arthritis or inflammatory bowel disease (e.g., Crohn’s disease, ulcerative colitis).

Diagnosis

A diagnosis of bronchiectasis is typically confirmed with a high-resolution computed tomography (HRCT) scan of the chest. This imaging test provides a detailed view of the lungs and can clearly show the widened airways.

Because the condition often overlaps with others, further tests are usually conducted to investigate the underlying cause and guide treatment.

The Diagnostic Journey

1

Initial Scan

A high-resolution computed tomography (HRCT) scan provides a detailed view to confirm widened airways.

2

Blood Tests

To check for inflammatory markers, immune system function, and genetic markers.

3

Sputum Analysis

A sample of mucus is tested to identify any bacteria or fungi growing in the airways.

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Other Tests

Pulmonary Function Tests (PFTs) and other specialized tests may be used to find a root cause.

Treatment and Management

While there is currently no cure for bronchiectasis, treatment is essential for managing symptoms, reducing the frequency of exacerbations, preventing disease progression, and improving quality of life. Management is a multi-faceted approach focused on two main goals: tackling infections and improving mucus clearance.

Airway Clearance Techniques

This is a cornerstone of daily management. A respiratory physiotherapist can teach specific methods to help clear mucus from the lungs. These techniques include:

Active Cycle of Breathing (ACBT)

A set of breathing exercises to loosen and move mucus.

Positive Expiratory Pressure (PEP) Devices

Handheld devices (like an Acapella or Flutter) that use vibration and pressure.

Autogenic Drainage

A breathing technique using different breath speeds to move mucus.

Postural Drainage

Using gravity by positioning the body in different ways to help mucus drain.

Medications and Other Therapies

  • Antibiotics: Used to treat acute chest infections. In some cases, long-term or nebulized antibiotics may be prescribed to suppress chronic infections.
  • Mucolytics: Medications (like carbocisteine or nebulized saline) that help to thin the mucus, making it easier to cough up.
  • Bronchodilators: Inhaled medicines that help open up the airways, which can make breathing and mucus clearance easier.
  • Anti-inflammatories: Research is ongoing, but these may be used in some cases to help break the cycle of inflammation.

Pulmonary Rehabilitation

This is a comprehensive program that combines exercise, education, and support. It is highly effective at improving breathing, muscle strength, and overall fitness, which in turn can help with airway clearance and quality of life.

Living with Bronchiectasis

Effective day-to-day management is crucial for living well with bronchiectasis. This involves a partnership between the patient and their healthcare team.

Self-Management Plans

Many patients work with their doctor to create a self-management plan. This plan helps in monitoring daily symptoms, tracking medications, and provides clear instructions on what to do during an exacerbation (e.g., when to start antibiotics or increase airway clearance).

Lifestyle and Support

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Stay Active

Regular, moderate exercise is beneficial for general fitness and can also act as a form of airway clearance.

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Vaccinations

Staying up-to-date with flu and pneumonia vaccines is critical to prevent infections.

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Support Resources

Patient packs, self-care guides, and patient conferences provide valuable information and support.

Disclaimer: This page is for informational purposes only and does not constitute medical advice. Please consult with a healthcare professional for diagnosis and treatment.

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